CARCINOMA BRONCOGENICO [1 record] Cancers and Oncology; Bronchi A cancer of the lung, so-called because it arises from the epithelium of the. English Spanish online dictionary Term Bank, translate words and terms with different pronunciation options. Lung cancer, or frequently if somewhat incorrectly known as bronchogenic carcinoma is a broad term referring to the main histological subtypes of primary lung.

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Small-cell carcinoma also known as small-cell lung canceror oat-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung[1] although it can occasionally arise in other body sites, such as the cervix[2] prostate[3] and gastrointestinal tract. Compared to non-small cell carcinomasmall cell carcinoma has a shorter doubling time, higher growth fraction, and earlier development of metastases. Small-cell carcinoma of the csrcinoma usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways.

Common symptoms include cough, dyspnea, weight loss, and debility. Due to its high grade neuroendocrine nature, small-cell carcinomas can produce ectopic hormonesbroncogdnico adrenocorticotropic hormone ACTH and anti-diuretic hormone ADH. Lambert-Eaton myasthenic syndrome LEMS is a well-known paraneoplastic condition linked to broncogemico carcinoma. When associated with the lung, it is sometimes called “oat cell carcinoma” due to the flat cell shape and scanty cytoplasm.

Small-cell carcinoma is most often more rapidly and widely metastatic than non-small cell lung carcinoma [7] and hence staged differently. There is usually early involvement of the hilar and mediastinal lymph nodes.

Small-cell lung carcinoma can occur in combination with a carcinomaa variety of other histological variants of lung cancer[8] including extremely complex malignant tissue admixtures.

Although combined small-cell lung carcinoma is currently staged and treated similarly to “pure” small-cell carcinoma of the lung, recent research suggests surgery might improve outcomes in very early stages of this tumor type. Symptoms and signs are as for other lung cancers. In addition, because of their neuroendocrine cell origin, small-cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome.

Very rarely, the primary site for small-cell carcinoma is outside of the lungs and pleural space, it is referred to as extrapulmonary small-cell carcinoma EPSCC. Outside of the respiratory tract, small-cell carcinoma can appear in the cervix, prostate, liver, pancreas, gastrointestinal tract, or bladder. Histologically similar to small-cell lung cancer, therapies for small-cell lung cancer are usually used to treat EPSCC.

In Japan, the first line treatment is shifting to irinotecan and cisplatin. This is an extremely rare type of small cell, and there has been little information in the scientific community. It appears to occur in only one or more lymph nodes, and nowhere else in the body. Treatment is similar to small cell lung cancer, but survival rates are much higher than other small-cell carcinomas.


Small-cell carcinoma

It can metastasize to the brain. Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in small-cell carcinomas are smaller than normal cells, and barely have room for any cytoplasm.

Some researchers identify this as a failure in the mechanism that controls the size of the cells. Small-cell lung carcinoma has long been divided into two clinicopathological stages, including limited stage LS and extensive stage ES. The stage is generally determined by the presence broncofenico absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy portal.

If the cancer has spread beyond that, it is said to be ES. However, relapse rate remains high, and median survival is only 18 to 24 months. In ES-SCLC, platinum-based combination chemotherapy is the standard of care, [23] with radiotherapy added only to palliate symptoms carcinomw as dyspneapain from liver or bone metastases, or for treatment of brain metastaseswhich, in small-cell lung carcinomatypically have a rapid, if czrcinoma, response to whole brain radiotherapy.

Combination chemotherapy consists of a wide variety of agents, including cisplatincyclophosphamidevincristine and carboplatin. Responses in ES-SCLC are often of short duration, and the evidence surrounding the risk of treatment compared to the potential benefit of chemotherapy for people who have extensive SCLC is not clear. If complete response to chemotherapy occurs in a subject with SCLC, then prophylactic cranial irradiation PCI is often used in an attempt to prevent the emergence of brain metastases.

Although this treatment is often effective, it can cause hair loss and fatigue. Prospective randomized trials with almost two years follow-up have not shown neurocognitive ill-effects. Meta-analyses of randomized trials confirm that PCI provides significant survival benefits. All in all, small-cell carcinoma is very responsive to chemotherapy and radiotherapyand in particular, regimens based on platinum-containing agents.

However, most people with the disease relapse, and median survival remains low.

Principles and practice of radiation therapy. From Wikipedia, the free encyclopedia. Small-cell carcinoma Micrograph of a small-cell carcinoma of the lung showing cells with nuclear mouldingminimal amount of cytoplasm and stippled chromatin. Combined small-cell lung carcinoma. Anaplastic microcellular, oat cell carcinoma from the lung histopathology. Histopathologic image of small-cell carcinoma of the lung.


CT-guided core needle biopsy. Archived from the original on Robbins Basic Pathology 8th ed. Robbins and Cotran pathologic basis of disease. World Health Organization Classification of Tumours.

Archived PDF from the original on 23 August Retrieved 27 March Eur J Cardiothorac Surg. Orphanet Journal of Rare Diseases. Journal of the Royal Carvinoma of Medicine. Can J Neurol Sci.

Translocations in Small Cell Carcinoma”. Archived from the original on bbroncogenico January Retrieved 30 April How does a cell know its size?

The Cochrane Database of Systematic Reviews See image page in Commons for percentages in numbers. Table 2 Archived at the Wayback Machine.

Cáncer de pulmón, propuesta ética para agilizar su diagnóstico

Journal of Clinical Oncology. Glandular and epithelial neoplasms ICD-O Small cell carcinoma Combined small cell carcinoma Verrucous carcinoma Squamous cell carcinoma Basal cell carcinoma Transitional cell carcinoma Inverted papilloma. Renal cell carcinoma Endometrioid tumor Renal oncocytoma. Lobular carcinoma in situ Invasive lobular carcinoma.

Medullary carcinoma of the breast Medullary thyroid cancer. Warthin’s tumor Thymoma Bartholin gland carcinoma. Epithelium and epithelial tissue.

Location of lung carcinoma in relation to the smoking habit and gender

Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis. Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell bronfogenico.

Sarcoma Lymphoma Immature teratoma Melanoma. Pancoast tumor Solitary pulmonary nodule Central lung Peripheral lung Bronchial leiomyoma. Mesothelioma Malignant solitary fibrous tumor. Sertoli-Leydig cell tumour Sertoli cell tumour Leydig cell tumour.

Seminoma Spermatocytic seminoma Intratubular germ cell neoplasia. Retrieved from ” https: Carcinoma Lung cancer Cytopathology Infectious causes of cancer. Webarchive template wayback links Infobox medical condition new All articles with unsourced statements Articles with unsourced statements from December Views Read Edit View history.

In other projects Wikimedia Commons. This page was last edited on 17 Octoberat By using this site, you agree to the Terms of Use and Privacy Policy. Micrograph of a small-cell carcinoma of the lung showing cells with nuclear mouldingminimal amount of cytoplasm and stippled chromatin.

Complex epithelial Warthin’s cxrcinoma Thymoma Bartholin gland carcinoma. Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma. Testicles Sex cord- gonadal stromal Sertoli-Leydig cell tumour Sertoli cell tumour Leydig cell tumour.

G Seminoma Spermatocytic seminoma Intratubular germ cell neoplasia.